ICAP’26

17:30–19:00

Conference Registration | Hall Room Costa Azul – 8th floor

19:30

Welcome Dinner &

Portuguese Fado Music Performance

8:30

Opening session | Room Costa Azul – 8th floor

9:00 - 9:40

Plenary 1. Jacek R. Wiśniewski, Max-Planck-Institut für Biochemie (Germany)

The proteomic sample preparation hurdle

9:40 – 10:20

Plenary 2. Jiri Adamec, LSUHSC – School of Medicine (USA)

Integration of precision and population-based medicine: from population to individuals and back

10:20 – 10:40

Keynote 1. Cristina Banfi, Centro Cardiologico Monzino IRCCS (Italy)

Advanced Quantitative Proteomics Identifies a Novel Multifunctional Regulator Linking Adipogenesis, Thrombosis, and Atherosclerosis

10:40 – 11:30

Coffee Break | Poster Session & Networking

11:30 – 12:10

Plenary 3. Ellen D. McPhail, Mayo Clinic (USA)

Evolution of amyloid typing for precision diagnostics and optimal patient care: From immunohistochemistry to shotgun proteomics to optical spectroscopy/artificial intelligence

12:10 - 12:30

Keynote 2. Sonia Sharma, La Jolla Institute for Immunology (USA)

Bioactive Lysophospholipids Modulate Responses and Toxicity to Immune Checkpoint Blockade

12:30 - 12:50

Keynote 3. Taicia Fill, State University of Campinas (Brazil)

Decoding virulence in Penicillium italicum: A functional link between NRPS-derived cyclic peptides and citrus infection

13:00 – 14:30

Lunch

14:45 – 15:00

O.A1 | Eiva Bernotiene, State Research Institute Centre for Innovative Medicine

(Lithuania) Proteomic analysis of menstrual blood extracellular vesicles reveals non-invasive biomarkers for unexplained infertility

15:00 – 15:15

O.A2 | Maxim V. Berezovski, University of Ottawa (Canada)

CE−MS Metabolomic and LC−MS Proteomic Analyses of Breast Cancer Exosomes Reveal Alterations in Purine and Carnitine Metabolism

15:15 – 15:30

O.A3 | Alexander Khmaladze, University at Albany SUNY (USA)

Integrative Spectro-Proteomics for Opioid Neurotoxicity: Fentanyl-Induced Alterations in Lipid Droplets and Phosphoprotein Networks

15:30 – 15:45

O.A4 | Eliška Benešová , Masaryk University (Czech Republic)

Multiplex Proteomic Assay for Relative Quantification of Neurodevelopmental Biomarkers

15:45 – 16:00

O.A5 | Veronika Vidova, Masaryk University (Czech Republic)

Multiplexed proteomics assay for quantification of clinically relevant proteins, their isoforms and significant SNPs

16:00 – 16:15

O.A6 | Renata Marino Romano, State University of Central-West (Brazil)

New insights into male infertility revealed by high-resolution mass spectrometry

16:15 – 17:00

Coffee Break & Networking

17:00 – 17:15

O.A7 | Ana Xavier-Magalhaes, Genentech Inc. (USA)

Not lost in translation: Informing the proteome with ribosome profiling

17:15 – 17:30

O.A8 | Masood Kamali-Moghaddam, Uppsala University (Sweden)

Advance Molecular Tools for Detection and Characterization of Proteins and Extracellular Vesicles

17:30 – 17:45

O.A9 | Cristina Contini, University of Cagliari (Italy)

Unrevealing the cerebrospinal fluid endogenous peptidome from Multiple Sclerosis and Neuromyelitis Optica patients

17:45 – 18:00

O.A10 | Davide Ricci, Università degli Studi di Palermo (Italy)

First proteome-wide assessment of translational readthrough therapy effects in liver in a cystic fibrosis mouse model, supporting NV848 advancement to clinical studies

18:00 – 18:15

O.A11 | Jennie Lill, Genentech Inc. (USA)

TEAD-targeting small molecules trigger a cofactor switch to modulate the Hippo pathway

18:15 – 18:30

O.A12 | F. Alves, The University of Melbourne (Australia)

Largescale multiomic modelling of human brain reveals metabolic adaptation that precedes bioenergetic collapse in Alzheimer’s disease

14:45 – 15:00

O.B1 | Sha Sha, German Cancer Research Center (Germany)

Exploring Inflammation-related Proteomic Biomarkers for Long-Term Risk Prediction of Gastroesophageal Cancer in Two European Cohorts

15:00 – 15:15

O.B2 | Jiansheng Liang, University of Science and Technology (China)

Proteome-Transcriptome Discordance in Rice under Drought ls Modulated by Post- Translational Modifications with Functional Consequences for Photosynthesis and Energy Metabolism

15:15 – 15:30

O.B3 | Ben Schöttker, German Cancer Research Center (Germany)

Next-generation proteomics improves lung cancer risk prediction

15:30 – 15:45

O.B4 | Yan Xiong, Icahn School of Medicine at Mount Sinai (USA)

Harness the Deubiquitinases for Targeting Protein Stabilization

15:45 – 16:00

O.B5 | René Lenobel, Palacký University (Czech Republic)

Distinct Systemic Immune and Lipid-Associated Responses Differentiate Myocardial Infarction from Degenerative Aortic Stenosis

16:00 – 16:15

O.B6 | Jaroslava Friedecká, Palacký University (Czech Republic)

Time-Dependent Molecular Remodeling of the Vitreous in Retinal Detachment Reveals a Window of Biological Reversibility

16:15 – 17:00

Coffee Break & Networking

17:00 – 17:15

O.B7 | Anna Bukiya, The University of Tennessee Health Science Center (USA)

Proteomics analysis of fetal baboon cerebral artery points at mitochondria as a new player in the pathophysiology of fetal alcohol spectrum disorders

17:15 – 17:30

O.B8 | Ilaria Iacobucci, University of Naples Federico II (Italy)

A multi-omics integrated approach to prioritize biomarker candidates associated in breast cancer

17:30 – 17:45

O.B9 | Martin Kussmann, Kussmann Biotech GmbH (Germany)

Omics & AI as Lenses into Molecular Human Nutrition and Health

17:45 – 18:00

O.B10 | Tatiana Rogasevskaia, University of Calgary (Canada)

The role of the membrane transporter NCKX5 in skin pigmentation

18:00 – 18:15

O.B11 | Stefani N. Thomas, University of Minnesota School of Medicine (USA)

Translating predictive biomarker candidates of drug treatment sensitivity in ovarian cancer to verified biomarkers

9:00 – 9:40

Plenary 4. Nataly Kravchenko-Balasha, The Hebrew University of Jerusalem

(Israel) A Patient Specific Framework to Guide Anti-Tumor and Immune-Modulatory Targeted Therapies and Predict Immunotherapy Efficacy

9:40 – 10:20

Plenary 5. Jean Pieters, University of Basel (Switzerland)

Coronin Proteins: Controllers of Cell Population Size and Multicellularity

10:20 – 10:40

Keynote 4. Michele Mishto, Francis Crick Institute (UK)

Production, antigenicity and immunogeneicity of proteasome-generated spliced peptides

10:40 – 11:00

Keynote 5. Shay Sharon, Hadassah and Hebrew University Medical Center,

Jerusalem (Israel) From the Lab to the Operating Room – Translating Novel Therapies to Treat Head and Neck Cancer

11:00 – 11:30

Coffee Break | Poster Session & Networking

11:30 – 12:10

Plenary 6. Angel Porgador, Ben-Gurion University of the Negev, Beer Sheva

(Israel) Immune Checkpoints Revisited: Novel Ligands, Targeted Therapeutics, and the Glycan Dimension

12:10 – 12:30

Keynote 6. Luigi Puglielli, University of Wisconsin-Madison (USA)

Acetyl-CoA and proteostasis

12:30 – 12:50

Keynote 7. Alan J. Stewart, University of St Andrews (UK)

Integrated proteomic and metalloproteomic analysis of haemostatic dysfunction in diabetes

12:50

Conference Picture

13:00 – 14:00

Lunch

14:15 – 20:00

Visit to Lisbon Downtown

9:00 – 9:40

Plenary 7. Namrata D. Udeshi, Broad Institute of MIT and Harvard (USA)

Decoding Cell Surface and Vascular Protein Landscapes for Therapeutic Discovery

9:40 – 10:00

Keynote 8. Roopali Roy, Boston Children’s Hospital (USA)

Mining the Urinary Proteome: Identification and Validation of Non-invasive Biomarkers for Detection of Cancer

10:00 – 10:20

Keynote 9. Jun Wang, Stony Brook University (USA)

Single-Cell MIST: An Open Platform for Single-Cell Proteomics and Spatial Biology

10:30 – 11:30

Coffee Break | Poster Session & Networking

11:30 – 12:10

KPRK1. Marco Arruda, Institute of Chemistry Substitute Executive

Director – Funcamp University of Campinas – Unicamp (Brazil) Elemental Meets Molecular: Multimodal platform for Speciomics

12:10 – 12:30

Keynote 10. Bruno Manadas, University of Coimbra (Portugal)

Enhancing Mesenchymal Stem Cell Therapy for Neonatal HIE: The Impact of Hypoxia- Preconditioning on Proteostasis and Neuroprotection

12:30 – 12:50

Keynote 11. Noa Martín Cófreces, Instituto de Investigación Sanitaria

Hospital Universitario La Princesa (Spain) Differential proteome and post-translational modifications changes at the centrosome during T lymphocyte activation

13:00 – 14:30

Lunch

14:30 – 14:50

Keynote 12. Yuichi J. Shimada, Columbia University Irving Medical Center

(USA) Comprehensive Proteomic Profiling of Human Myocardium Reveals Signaling Pathways Dysregulated in Hypertrophic Cardiomyopathy

14:50 – 15:10

Keynote 13. Anders Christensson, Lund University (Sweden)

Selective Glomerular Hypofiltration relates to atherosclerosis promoting proteins and glucometabolic disturbances connecting it to cardiovascular disease and total mortality

15:10 - 15:25

O.A13 | Victor H. Villar, University of St Andrews (UK)

L-pentahomoserine correlates with therapy outcome in esophageal cancer and promotes metabolic adaptations that support cell survival under nutrient-deprived conditions

15:25 - 15:40

O.A14 | Helen Miranda, Case Western Reserve University (USA)

Skeletal Muscle Cell Fate Determines Neuromuscular Junction Integrity in SBMA

15:40 – 16:30

Coffee Break & Networking

16:30 - 16:45

O.A15 | Guillaume Médard, National and Kapodistrian University of Athens

(Greece) Dose-resolved competitive pulldowns with bottom-up proteomics readout reveal the off-targets of HDAC drugs

16:45 - 17:00

O.A16 | Aaron Wacholder, Institute of Molecular Systems Biology (Switzerland)

Finding proteins hidden in the dark proteome

17:00 - 17:15

O.A17 | Emanuele Micaglio, Multimedica Hospital (Italy)

Genotype - Phenotype correlations among 376 consecutive patients affected by Cardiomyopathies

17:15 - 17:30

O.A18 | Luis B. Carvalho, Instituto Nacional de Saúde Dr. Ricardo Jorge (INSA)

(Portugal) Expanding the Molecular Landscape of Human Red Blood Cells

17:30 - 17:35

SG.01 | André Q. Figueiredo, NOVA School of Science and Technology (Portugal)

Beyond ELISA: Towards Proteome-Wide Plasma Protein Quantification Using the Total Protein Approach

17:35 - 17:40

SG.02 | Gonçalo B. Vieira, NOVA School of Science and Technology (Portugal)

Urinary Proteomics as a Potential Guide for Patient-Specific Treatment Strategies in Breast Cancer

17:40 - 17:45

SG.03 | Manuela Iacobini, Sapienza University of Rome (Italy)

Exploiting the Personalized Protein Corona as a Disease-Specific Molecular Fingerprint for Nanodiagnostics

17:45 - 17:50

SG.04 | Joyce Andrade da Silva, Sao Paulo State University (UNESP) (Brazil)

Metalloproteomic Signatures of Mercury Exposure in Traditional Amazonian Populations

17:50 - 17:55

SG.05 | Riccardo Varrica, University of Palermo (Italy)

Targeting premature stop codons in DMD: Preliminary functional rescue and proteomic roadmap for multi-organ marker analysis

18:00 – 19:00

Chillout Shotgun Poster Session – Room Costa Azul (8th Floor)

20:00 – 21:00

Gala Dinner – Atlantida Restaurant – 8th Floor

21:00 – 22:00

Classical Music Concert • Poster Awards Ceremony

22:00 – 00:00

Cultural and Social Gathering with Queimada and International Drinks

9:00 - 9:40

Plenary 8. Ute Distler, University Medical Center of the Johannes

Gutenberg University Mainz (Germany) Multicenter Evaluation of Label-Free Quantification in Plasma: Benchmarking with a High Dynamic Range Multispecies Sample Set

9:40 – 10:20

Plenary 9. Pierre Olivier-Schmit, Bruker (France)

Available Soon

10:20 - 10:40

Keynote 14. Ieronymos “Makis” Zoidakis, National and Kapodistrian

University of Athens (Greece) Bladder cancer biomarker ruin in urine

10:40 – 11:30

Coffee Break & Networking

11:30 - 12:10

Plenary 10. Hugo M. Santos, NOVA University of Lisbon (Portugal)

Beyond Protein Lists: Decoding Dynamic Biological Systems Through Proteomics

12:10 - 12:50

Plenary 11. Daniel Martins-de-Souza, University of Campinas (Brazil)

Depression from a proteomic perspective

12:50 – 13:00

Shotgun Awards Ceremony & Closing Ceremony

13:00 – 14:30

Lunch

Poster

P.1 | Álvaro Gómez Morón, Hospital Universitario de La Princesa (Spain)

Tubulin-binding cofactor B (TBCB) at the Crossroads of Cytoskeletal Dynamics and Metabolic Reprogramming in the Immune Synapse

Poster

P.2 | Ismail Kirrout-Flores, Instituto de Investigación Sanitaria Hospital Universitario La

Princesa (Spain) LC–MS/MS proteomics defines plocabulin-induced metabolic and extracellular vesicle remodeling in MC38 cells

Poster

P.3 | Natalia Andelova, Slovak Academy of Sciences (Slovak Republic)

Quantitative Proteomic Mapping Reveals Cardioprotective Remodeling of the Mitochondrial Respiratory Chain under Reduced Oxygen Utilization

Poster

P.4 | Madleen Nabeel Al-Qusous, University of Strathclyde (UK)

Discovering predictive proteomic signatures of frailty and mortality in emergency laparotomy surgical patients

Poster

P.5 | Haleema Sadia Ahmed, University of Strathclyde (UK)

Integrative Proteomic Profiling Identifies Mitochondrial Dysfunction During Cellular Ageing

Poster

P.6 | Ľudovít Paulis, Comenius University (Slovak Republic)

Combined RAAS modulation reveals proteomic remodeling of angiotensin peptide networks in plasma and tissues

Poster

P.7 | Mariana Dias, NOVA School of Science and Technology (Portugal)

Longitudinal Urinary Proteomics Characterizes Treatment-Associated Molecular Changes in Metastatic Colorectal Cancer Undergoing FOLFIRI Chemotherapy: A Case Study

Poster

P.8 | Inês F. Domingos, NOVA School of Science and Technology (Portugal)

Hematuria Is Not Simply Blood in Urine: Urinary Proteomic Logic Gates Reveal Distinct Molecular States

Poster

P.9 | João M. R. A. Montes, NOVA School of Science and Technology (Portugal)

Molecular GPS for Cancer: State-Space Reconstruction from Longitudinal Urinary Proteomes

Poster

P.10 | Raquel Fonseca, NOVA School of Science and Technology (Portugal)

One Tooth, Multiple Stories: Ultrasound-Assisted Dental Peptidomics for Sex Estimation, Dietary Signals, and Microbial Detection

Poster

P.11 | Bárbara Lopes, National Institute of Health Dr Ricardo Jorge (Portugal)

Multi-Omic profiling of red blood cells in Obstructive Sleep Apnea

Poster

SG.01 | André Q. Figueiredo, NOVA School of Science and Technology (Portugal)

Beyond ELISA: Towards Proteome-Wide Plasma Protein Quantification Using the Total Protein Approach

Poster

SG.02 | Gonçalo B. Vieira, NOVA School of Science and Technology (Portugal)

Urinary Proteomics as a Potential Guide for Patient-Specific Treatment Strategies in Breast Cancer

Poster

SG.03 | Manuela Iacobini, Sapienza University of Rome (Italy)

Exploiting the Personalized Protein Corona as a Disease-Specific Molecular Fingerprint for Nanodiagnostics

Poster

SG.04 | Joyce Andrade da Silva, Sao Paulo State University (UNESP) (Brazil)

Metalloproteomic Signatures of Mercury Exposure in Traditional Amazonian Populations

Poster

SG.05 | Riccardo Varrica, University of Palermo (Italy)

Targeting premature stop codons in DMD: Preliminary functional rescue and proteomic roadmap for multi- organ marker analysis